The identities of these species were confirmed by mass spectrometry ( Supplementary Material, Figs S1 and S2 ). Measurement of native purified protein size (hydrodynamic diameter) using dynamic light scattering (DLS) revealed that MBP-ΔNCP69 forms larger species compared with MBP-ΔN597, although this fell just short of statistical significance ( P = 0.056, Fig. 3 D).
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A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
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