The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome.

PLoS One · 2012 · PMC3392214 · PMID 22792322

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highly significantno p-value reported

Notably, MEF Trim50 −/− cells treated with MG132 showed a highly significant reduction of all three parameters compared to the wild type and heterozygous mouse cell lines, respectively ( Figure 5B ).

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