Weight loss is still an essential intervention in obesity and its complications: a review.

J Obes · 2012 · PMC3395150 · PMID 22811888

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highly significantno p-value reported

Weight loss program also reported to have resulted in a highly significant improvement in symptoms in overweight patients with knee osteoarthritis [ 23 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.