highly significantp < 0.001
Hence, neurotoxicity of srVSV(ΔG/ΔL) was at least >700-fold reduced if compared to VSV-WT with differences in survival between srVSV- and VSV-WT-treated cohorts being highly significant ( p < 0.001). srVSV(ΔG/ΔL) is a potent type I IFN inducer As it was previously shown that type I IFN-inducing strains of VSV were strongly attenuated regarding their toxicity [ 26 ], the capacity of srVSV(ΔG/ΔL) to induce IFN was evaluated in murine pDC cultures. pDCs were infected with either srVSV(ΔG/ΔL), VSV*ΔG, VSVΔL-DsRed, or VSV-WT as negative and VSV*M Q as positive control at an MOI of 2.