Physical tethering and volume exclusion determine higher-order genome organization in budding yeast.

Interchromosomal locus-locus contacts The interchromosomal contact frequencies in the structure population are correlated with those observed in experiments, with an average Pearson's correlation of 0.54, which is highly significant ( P < 10 −15 ) ( Fig. 3E,F ; Supplemental Fig. 2D).

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