RIP-chip-SRM--a new combinatorial large-scale approach identifies a set of translationally regulated bantam/miR-58 targets in C. elegans.

2A ), there was a highly significant bias among genes containing potential bantam/miR-58 seed binding sites (7-mers, one mismatch allowed) to be depleted (log 2 RIP “ mir-58 ”/“wild-type” < 0) in the “ mir-58 ” RIPs ( P -value = 6.3 × 10 −8 , hypergeometric distribution) ( Fig. 2A ).

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