Functional differences exist between TNFα promoters encoding the common -237G SNP and the rarer HLA-B*5701-linked A variant.

PLoS One · 2012 · PMC3396654 · PMID 22808100

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may be significantno p-value reported

Nonetheless, a modest impact on TNFα production may be significant, as positive feedback loops leading to enhanced TNFα production might amplify the impact of this SNP in vivo [33] .

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.