Evolution of animal Piwi-interacting RNAs and prokaryotic CRISPRs.

Brief Funct Genomics · 2012 · PMC3398257 · PMID 22539610

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highly significantno p-value reported

The existence of a seed sequence would be highly significant for the evolution of CRISPRs since it would drastically reduce the amount of sequence in the CRISPR spacer under selective constraint and allow for rapid evolution of new targets.

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