highly significantp < 0.0001
The results are statistically highly significant WOMAC osteoarthritis index at V1: (4.24 ± 1.94/6.19 ± 1.79; p < 0.0001, t test and Wilcoxon test), not significant at V2: p = 0.1636, highly significant at V3: p = 0.0009, and significant at V4: p = 0.0123 (Fig. 4 ).