highly significantP -value ≤ 5.1 × 10 −17
Further search for 4-mers enriched around tyrosine phosphorylation sites yielded three highly significant motifs: DFGL ( P -value ≤ 5.1 × 10 −17 ), HRDL ( P -value ≤ 7.7 × 10 −17 ) and SDVW ( P -value ≤ 2.5 × 10 −16 ).