Germline ablation of SMUG1 DNA glycosylase causes loss of 5-hydroxymethyluracil- and UNG-backup uracil-excision activities and increases cancer predisposition of Ung-/-Msh2-/- mice.

Nucleic Acids Res · 2012 · PMC3401444 · PMID 22447450

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highly significantno p-value reported

Indeed, not only is the reduced mean life expectancy of the triple knockout mice statistically highly significant, it is also most striking that all deaths in the triple knockout mice occurred before 152 days of age whereas the mean life expectancy of all the other single/double knockout strains analysed is ≥157 days.

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