Identification of novel subgroup A variants with enhanced receptor binding and replicative capacity in primary isolates of anaemogenic strains of feline leukaemia virus.

Given that the development of FeLV-associated erythroid hypoplasia is marked by a shift in receptor usage from THTR1 to FLVCR, the enhanced binding afforded by the DD mutation may be highly significant in the spread of such variants into compartments expressing the FLVCR receptor; this likely represents the first step towards the biological selection of subgroup C viruses.

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