Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors.

After ischemia, active linaclotide had no effect on TER (Figure 1A ), resulted in a barely significant, dose-independent decrease in 3 H-mannitol flux (Figure 1B ), caused a small increase in occludin (Figure 1C ) and had no effect on Isc (Figure 1D ).

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