The null hypothesis of HWE is rejected at 4 of 5 loci (HLA-A with p = 3.6E-08, HLA-B with p = 1.4E-10, HLA-DRB1 with p = 2.7E-10 and HLA-DQB1 with p = 0.023, the p-values for HLA-A, -B and -DRB1 remaining highly significant after correction for multiple tests on the 5 loci).
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