Phosphatase PPM1A negatively regulates P-TEFb function in resting CD4(+) T cells and inhibits HIV-1 gene expression.

Retrovirology · 2012 · PMC3406988 · PMID 22727189

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closest p

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likely to be significantno p-value reported

~2.5-fold Figure 4 ref [ 23 ]), the effect is likely to be significant given that quiescent CD4 + T lymphocytes are difficult to transfect with siRNAs and are metabolically inactive and carry out low levels of protein synthesis.

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