Empiric antibiotic, mechanical ventilation, and central venous catheter duration as potential factors mediating the effect of a checklist prompting intervention on mortality: an exploratory analysis.

In particular, Aarts and coworkers reported that prolonged empiric antibiotic therapy (>4days) in patients without nosocomial infection was associated with an almost 4-fold increase in the age- and risk-adjusted odds of death that almost reached statistical significance [ 9 ].

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