A comprehensive characterization of genome-wide copy number aberrations in colorectal cancer reveals novel oncogenes and patterns of alterations.

Highly significant GISTIC peaks not associated with well-established oncogenes or tumor suppressors include 12 p13.33 ( Figure 2E, F ) and 20 q13.12 ( Figure 2G, H ), which had recurrent high-magnitude focal amplifications, as well as 14 q32.31 which, although not highly amplified, had gains of sufficient recurrence and focality as to render a highly significant GISTIC Q-value ( Figure 1B , Table S3 ).

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