Small protease sensitive oligomers of PrPSc in distinct human prions determine conversion rate of PrP(C).

PLoS Pathog · 2012 · PMC3410855 · PMID 22876179

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highly significantno p-value reported

The amplification rates inversely correlate with the stability of sCJD sPrP Sc Comparison of the stability of total PrP Sc with the amplification efficacy of individual sCJD PrP Sc seeds demonstrate a highly significant inverse correlation for both MM1 (n = 10) and MM2 (n = 10) sCJD samples, and in both sPMCA and QuIC ( Fig. 4D ).

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