Evolution of signal multiplexing by 14-3-3-binding 2R-ohnologue protein families in the vertebrates.

Open Biol · 2012 · PMC3411107 · PMID 22870394

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It may be significant that several 14-3-3-binding singletons belong to ancient multi-protein complexes: Rictor, raptor and PRAS40/AKTS1 are in the nutrient-sensing mTOR (mammalian target of rapamycin) complexes; BAD and B2L11 are central components of the apoptotic machinery; and EDC3 (enhancer of mRNA-decapping protein 3) is part of an mRNA-decapping complex [ 44 , 45 ].

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