Mixed vector immunization with recombinant adenovirus and MVA can improve vaccine efficacy while decreasing antivector immunity.

Mol Ther · 2012 · PMC3412496 · PMID 22354374

Europe PMC DOI

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closest p · 1.2× alpha

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not quite statistically significantP = 0.06so close (0.05 < p ≤ 0.1)

We observed, in agreement with the results obtained from the parasite counts in blood, that the parasite burden in the liver appeared to be lower in the ChAd63+MVA group than in the ChAd63 or naive groups, although the differences were not quite statistically significant [mean for ChAd63 = 235,850 relative light unit, ChAd63+MVA = 122,367 relative light unit, 95% CI (−10,197 to 237,164), P = 0.06 by a t -test] ( Figure 2b,c) .

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a nonsignificant trendno p-value reported

As compared to a control group (no pre-exposure followed by Ad+MVA, mean of 17,108 SFC/million PBMCs), Pb9-specific responses showed a nonsignificant trend to reduction in mice pre-exposed to MVA-85A (mean 14,294 SFC/million PBMCs.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.