HAL-2 promotes homologous pairing during Caenorhabditis elegans meiosis by antagonizing inhibitory effects of synaptonemal complex precursors.

While pairing at this locus was abolished throughout the gonad in the hal-2 single mutant, the syp-3; hal-2 double mutant exhibited a highly significant increase in pairing over the hal-2 single mutant specifically in Zone 2 (p<0.0001), the same zone in which chromosome V PCs were shown to be active in the hal-2; syp-2 double mutant.

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