Potential novel therapeutic strategies in cystic fibrosis: antimicrobial and anti-biofilm activity of natural and designed α-helical peptides against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia.

The activity of AMPs and Tobramycin against preformed biofilms resulted to be similar in 5 out of 6 strains tested, causing a highly significant reduction of biofilm viability compared to the controls (biofilm not exposed; p < 0.0001), regardless of the concentrations tested (Figure 3 ).

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