Barely Significant
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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study.

J Neuroinflammation · 2012 · PMC3419089 · PMID 22824372

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an overall trendno p-value reported
While in the HC, classical MHC class II genes showed an overall trend toward progressively increased upregulation in aging and AD, only one probe set met the statistical criteria of a ‘continuum’ gene.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.