The human milk protein-lipid complex HAMLET sensitizes bacterial pathogens to traditional antimicrobial agents.

When using the erythromycin-resistant strain JY53 that displayed a 100-fold higher MIC, combination treatment with the two agents at the same concentrations was somewhat less effective but still caused a bactericidal activity significantly higher than the additive killing of each agent alone ( P <0.05), which could be increased to complete eradication of the bacterial inoculum when 300 μg/ml erythromycin ( P <0.001) was used together with 50 μg/mL HAMLET, a highly significant synergy in killing of erythromycin-resistant pneumococci ( Figure 2D ).

also in 132,142 other papers