Fractalkine Mediates Communication between Pathogenic Proteins and Microglia: Implications of Anti-Inflammatory Treatments in Different Stages of Neurodegenerative Diseases.

Int J Alzheimers Dis · 2012 · PMC3420133 · PMID 22919540

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Therefore, understanding the critical interplay between proinflammatory (TNF- α , IL-6, IL-1 β , and IL-1 α ), anti-inflammatory cytokines (IL-10, TGF- β , IL-34, etc.), and fractalkine levels to modulate microglial activity is highly significant.

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