Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers.

Since the enriched functional categories (i.e., inflammatory and immune responses) and tissue-specific gene expression patterns (macrophage- and leukocyte-enriched) are very similar between inflammatome and MEMNs, we performed a comparison among the inflammatome signature, mouse-derived MEMN, and human-derived MEMN gene sets and found highly significant overlaps between any two of these sets ( Figure 3 ).

also in 132,142 other papers