failed to reach significancep = 0.092
Unlike spontaneous neuronal firing, however, high potassium-induced neuron firing was significantly suppressed upon activation of 5-HT1B receptors by anpirtoline in WT neurons, whereas the response to anpirtoline was significantly diminished in snGSK3β-KO neurons (two-way ANOVA; main effects of Genotype and Time, F(1,17) = 5.42, p <0.05 and F(1,17) = 14.14, p <0.05, respectively, but the interaction failed to reach significance, F(1,17) = 3.16, p = 0.092; Figure 3C-3E ). 3.