Roth et al looked melatonin stimulated, the expression of bone, sialoprotein genes, alkaline phosphatase and osteocalcin for a period of time from 5 to 9 days, founding a highly significant evidence for this relationship because the genes of many of the bone matrix proteins (BSP, ALP, OC, and SPARC) contain the sequence of bases (RGGTCA) required for nuclear receptor binding of melatoninRZR to its promoter region.
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