Effects of α-MSH on ischemia/reperfusion injury in the rat sciatic nerve.

tion of nitric oxide (NO) and TNF-α.[ 13 ] This property affords antioxidant protection during I/R by both reducing the levels of NO and lowering the generation of peroxynitrite, another reactant easily capable of initiating lipid peroxidation.[ 30 , 32 ] These indirect antioxidant actions of α-MSH may be significant in affording protection against neuronal injury.[ 13 ] α-MSH is known to have the ability to modulate CNS inflammation.

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