Acutely decreased thermoregulatory energy expenditure or decreased activity energy expenditure both acutely reduce food intake in mice.

Cessation of exercise decreased daily energy expenditure by 16±3% and reduced total food intake by 18±1% (both p<0.001 by pair-wise comparison) in mice housed at 28°C, while mice housed at 21°C demonstrated a 10±1% decrease in daily energy expenditure (p<0.001) and a 9±4% reduction in total food intake, although the latter failed to reach significance (p = 0.07).

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