44 - 47 This process, termed Pregnancy Associated Breast Cancer (PABC) is a rare event (0.3 cases/1,000 pregnancies) but highly significant due to the low survivability. 48 The underlying reason for this may be due to the fact that the microenvironment of the involuting mammary gland shares many similarities to the inflammatory microenvironment associated with breast tumors including a “reactive” stroma that is associated with increased invasion and metastasis.
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Why the stroma matters in breast cancer: insights into breast cancer patient outcomes through the examination of stromal biomarkers.
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