Barely Significant
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Linking influenza virus tissue tropism to population-level reproductive fitness.

PLoS One · 2012 · PMC3429484 · PMID 22952637

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a decreasing trendno p-value reported
The expanding cell pool deeper down the respiratory tract, in association with lower clearance rates, may result in optimal infectivity rates–that likewise maximize influenza virus reproductive fitness at the population level–to exhibit a decreasing trend towards deeper regions of the respiratory tract.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.