Risk factors of brain metastases in completely resected pathological stage IIIA-N2 non-small cell lung cancer.

observed that clinical bulky (≥2 cm) mediastinal lymph nodes was of borderline significance in predicting an increased risk of BM in IIB–IIIB NSCLC after multimodality treatment.[ 10 ] Wang et al. reported that a greater number of mediastinal lymph nodes and nodal regions with metastases predicted a higher risk of BM for stage III-N2 NSCLC.[ 13 ] Mamon et al. reported that the incidence of BM increased independently by the presence of residual nodal disease in 177 surgically treated IIIA (N2) NSCLC with/without neoadjuvant/adjuvant therapy.[ 11 ] In our study, on multivariate analysis, LNR ≥ 30 % was associated with an increased risk of BM and BM as the first relapse.

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