ATXN2-CAG42 sequesters PABPC1 into insolubility and induces FBXW8 in cerebellum of old ataxic knock-in mice.

PLoS Genet · 2012 · PMC3431311 · PMID 22956915

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highly significantno p-value reported

Our investigation into consequences of ATXN2 expansions for mRNA levels in a genome-wide transcriptome survey demonstrated a surprising scarcity of effects, with the notable exception of the highly significant, reproducible and specific dysregulation in the expression of two ATXN2 neighbour genes, Adam1a and Fbxw8 .

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