The highly significant enrichment of conserved HSEs, elevated PPARGC1A peak signals at these sites, and strong tendency of PPARGC1A and HSF1 to associate within multi-RFBRs are particularly striking and may have important implications for understanding the role of PPARGC1A in normal metabolic function and human disease.
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A highly integrated and complex PPARGC1A transcription factor binding network in HepG2 cells.
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