MS-275 sensitizes osteosarcoma cells to Fas ligand-induced cell death by increasing the localization of Fas in membrane lipid rafts.

3 This finding is highly significant because the FasL + lung is the most common, and usually the only, site for OS metastasis. 4 We have also shown that agents that upregulate Fas expression induce the regression of established OS lung metastasis in vivo. 5 , 6 , 7 , 8 This therapeutic activity depends on an intact Fas signaling pathway. 7 Therefore, understanding the mechanism of how drugs induce Fas upregulation or enhance sensitivity to FasL may help identify novel therapeutic agents for the treatment of patients with OS lung metastases.

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