Test-set Pathways For each of the tested pathways, with the exception of the Fc epsilon RI signaling, Fc gamma R-mediated phagocytosis, regulation of autophagy and T-cell receptor signaling pathways, KBAS was able to identify a model that classifies cases and controls with a highly significant p- value, ranging from 2.55×10 − 9 to 1.19×10 − 23 for the RA vs. 58C comparisons and from 1.23×10 − 9 to 1.64×10 − 22 for the RA vs.
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