Smchd1-dependent and -independent pathways determine developmental dynamics of CpG island methylation on the inactive X chromosome.

Dev Cell · 2012 · PMC3437444 · PMID 22841499

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highly significantno p-value reported

We found a highly significant overlap between class A (fast-methylating) CGIs and the combined category of methylated and intermediate CGIs in Smchd1 −/− XX MEFs (Pearson’s chi-square test, p = 7.43 × 10 −5 ), and similarly between class C (slow-methylating) CGIs and those that remain unmethylated in Smchd1 −/− MEFs (Pearson’s chi-square test, p = 1.35 × 10 −5 ).

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