A genome-wide screen in human embryonic stem cells reveals novel sites of allele-specific histone modification associated with known disease loci.

Epigenetics Chromatin · 2012 · PMC3438052 · PMID 22607690

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hedged sentence

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closest p · 0.0× alpha

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boldest claim

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highly significantP < 2.2 × 10 −16actually significant

Given that only 0.6% of all high-coverage sites were within 10 kb of a known imprinted locus, this is a substantial (29.3-fold), and highly significant enrichment of ASHM sites around imprinted regions ( P < 2.2 × 10 −16 , χ2 test).

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