of borderline significanceP = 0.05
When subjects were further divided into obese (BMI ≥ 25.0 kg/m 2 , n = 22) and lean (BMI<25.0 kg/m 2 , n = 32) groups, similar nonlinear trends were observed in both groups, which was of borderline significance in the obese group (two-way ANOVA, P = 0.05, Figure 1 B).