δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.

SNP associations were genome-wide significant with CC-BNT (P<2.4×10 −7 ) and CC-WRAT (P<1.0×10 −8 ), nearly genome wide significant with CC-LMI (P<6.0×10 −7 ), and highly significant with CC-LMD (P<1.3×10 −6 ), CC-HVOT (P<1.9×10 −6 ) and CC-TMTB (P<3.7×10 −6 ).

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