Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites.

Nucleic Acids Res · 2012 · PMC3439890 · PMID 22684627

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highly significantP -value <10 −16actually significant

This overlap is highly significant ( P -value <10 −16 , hypergeometric test where the intersection is 9000 between 700 000 conserved islands and 60 000 DHSs, assuming a total of 30 000 000 potential loci), consistent with the idea that sequence conservation at overlapping unannotated conserved island/DHS loci reflects the importance of regulatory factor binding to DNA.

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