Elevated urine heparanase levels are associated with proteinuria and decreased renal allograft function.

PLoS One · 2012 · PMC3441528 · PMID 23028487

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highly significantno p-value reported

A highly significant association was found between urine and plasma heparanase levels in transplanted patients, suggesting that heparanase is present systemically and can affect cells and tissues other than the kidney.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.