Chronic creatine kinase deficiency eventually leads to congestive heart failure, but severity is dependent on genetic background, gender and age.

There was no difference in the slopes ( P = 0.58), but the difference in elevation was highly significant ( P = 0.0004), indicating that WT and M/Mt-CK −/− hearts do not share the same relationship for d P /d t max versus heart rate, but instead run in parallel (i.e. for any given heart rate, d P /d t max is lower in M/Mt-CK −/− hearts).

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