The borderline significance of CENP-A on multivariate analysis for DRFS in the JBI dataset most likely reflects the strong prognostic role of CENP-A in ER-positive patients as seen in the Wang and TRANSBIG cohorts that did not receive systemic therapy.
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Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancer.
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