A novel small molecule FL118 that selectively inhibits survivin, Mcl-1, XIAP and cIAP2 in a p53-independent manner, shows superior antitumor activity.

PLoS One · 2012 · PMC3446924 · PMID 23029106

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highly significantno p-value reported

In this regard, our finding that FL118 inhibits its downstream targets (survivin, Mcl-1, XIAP, cIAP2) in a p53 status (wild type, null or mutant)-independent manner is highly significant.

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