In vitro and in vivo antitumor activity of a novel pH-activated polymeric drug delivery system for doxorubicin.

PLoS One · 2012 · PMC3454402 · PMID 23028490

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a decreasing trendno p-value reported

On contrary, distribution of DOX formulation in healthy organs gave a decreasing trend accompany by time from 2 to 24 h.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.