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ShRNA-targeted COMMD7 suppresses hepatocellular carcinoma growth.

PLoS One · 2012 · PMC3458015 · PMID 23049798

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an increasing trendno p-value reported
The incidence of HCC in China still shows an increasing trend due to the pre-existing endemic hepatitis B viral infection although the childhood vaccination plan against HBV has been in place for over two decades.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.