Barely Significant
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Nicotine exposure exacerbates development of cataracts in a type 1 diabetic rat model.

Exp Diabetes Res · 2012 · PMC3459283 · PMID 23049540

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a positive trendno p-value reported
The levels of the measured cytokines increased significantly in nicotine-treated and untreated diabetic animals versus controls and demonstrated a positive trend in the nicotine-treated diabetic rats.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.