Convergent transmission of RNAi guide-target mismatch information across Argonaute internal allosteric network.

PLoS Comput Biol · 2012 · PMC3459882 · PMID 23028290

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highly significantno p-value reported

This suggests that the dynamical perturbations emanating from the mismatch site do not cause a large structural change even though their energetic change is quite substantial and highly significant with respect to function.

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